Abstract: Mango (Mangifera indica L.) is one of the most valued tropical fruits and occupies a significant position in global horticulture, food trade, and nutritional security. Although the pulp is widely consumed in fresh and processed forms, the seed kernel is commonly discarded during domestic consumption and industrial processing, thereby contributing to substantial agro-industrial waste. Recent scientific investigations indicate that mango kernel is a chemically valuable biomass rich in starch, dietary fiber, proteins, lipids, phenolic compounds, flavonoids, tannins, tocopherols, and essential minerals. Such constituents have drawn increasing attention because of their potential medicinal and functional relevance.

Traditional systems of medicine have employed mango seed preparations in the management of diarrhea, dysentery, skin irritation, inflammation, and digestive disturbances. Contemporary studies further suggest that mango kernel exhibits antioxidant, antimicrobial, anti-inflammatory, antidiabetic, gastroprotective, and lipid-lowering properties. These observations support its possible utility in pharmaceutical, nutraceutical, cosmetic, and functional food sectors. However, despite promising laboratory evidence, many reported outcomes remain dependent upon extraction methods, cultivar variation, dosage conditions, and experimental design. Clinical validation and safety standardization are still limited.

The present study critically examines the medicinal value of mango kernel through an integrated review of its phytochemical profile, therapeutic applications, scientific limitations, and future industrial prospects. It also emphasizes the transformation of mango seed from neglected waste into a potentially valuable natural resource for sustainable health-oriented innovations [1]–[6].

Keywords: Mango Kernel, Mangifera indica, Medicinal Value, Phytochemicals, Antioxidant, Therapeutic Uses, Critical Analysis.